Aluminium lithium hydride → HCID 20356910, compound

HRID 1793631Notes

Reaction equation

HRID 1793631 reaction equation
[OH:1][CH:2]1[CH2:7][CH:6]2[CH2:8][CH2:9][CH:3]1[C:4](=O)[NH:5]2.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[CH:6]12[CH2:8][CH2:9][CH:3]([CH:2]([OH:1])[CH2:7]1)[CH2:4][NH:5]2

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 22022836HCID 22022836, compound

Product 1

HCID 20356910HCID 20356910, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Compound (4) can be reacted with LAH in solvent (such as THF), with reflux under nitrogen to yield 2-aza-bicyclo[2.2.2]octane-5-ol (5).

Workup

  1. temperaturewith reflux under nitrogen

Sources & evidence

ORD record
ord-b503178708944433a3d3b688745efb78
Source dataset
uspto-grants-2006_07
Patent number
US07081531B2

Reaction notes

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