Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(2-Bromoethyl)indole → 3-(2-Bromoethyl)-1-(6-chloroimidazo[2,1-b]thiazole-5-sulfonyl)indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(2-Bromoethyl)indole | HCID 76924 | — |
| 반응물 | 6-Chloroimidazo(2,1-b)(1,3)thiazole-5-sulfonyl chloride | HCID 2799717 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-(2-Bromoethyl)-1-(6-chloroimidazo[2,1-b]thiazole-5-sulfonyl)indole | HCID 11259349 | 58% |
반응 단계
A mixture of 3-(2-bromoethyl)indole (1.0 g, 4.46 mmol) and 6-chloroimidazo[2,1-b]thiazole-5-sulfonyl chloride (0.96 g, 1.1 eq.) in THF is treated with potassium t-butoxide (0.48 g, 1.1 equiv.) at room temperature, stirred for 16 h, quenched with saturated NaHCO3 and extracted with EtOAc. The extracts are combined, dried over MgSO4 and concentrated in vacuo to give the title product as a brown oil, 1.2 g (58% yield), identified by HPLC and mass spectral analyses.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07022701B2 |
| 출처 데이터셋 | uspto-grants-2006_04 |
| ORD ID | ord-6727cf8fca674d6b87d64708b6652158 |
| 출처 메모 | uspto-grants-2006_04 |