HCID 86595211, compound → HCID 86595210, compound

HRID 1793936Notes

Reaction equation

HRID 1793936 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][NH:12][C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[C:6]([N+:20]([O-])=O)[CH:5]=1)([CH3:3])[CH3:2]>C(O)C.[C].[Pd]>[NH2:20][C:6]1[CH:5]=[C:4]([CH:1]([CH3:2])[CH3:3])[CH:9]=[CH:8][C:7]=1[CH2:10][CH2:11][NH:12][C:13](=[O:19])[O:14][C:15]([CH3:16])([CH3:18])[CH3:17]

Participants

4

Reactant 1

HCID 86595211HCID 86595211, compound

Product 1

HCID 86595210HCID 86595210, compoundYield 98.7%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

To a solution of 92 mg of tert-butyl [2-(4-isopropyl-2-nitrophenyl)ethyl]carbamate in 2 mL of ethanol was added 20 mg of 10% palladium-carbon, and the mixture was stirred under hydrogen atmosphere at room temperature for 5 hours. The insoluble was removed by filtration, and the filtrate was concentrated under reduced pressure to give 82 mg of tert-butyl [2-(2-amino-4-isopropylphenyl)ethyl]carbamate.

Workup

  1. customThe insoluble was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-33df552e071d4bb5a29654b48748c713
Source dataset
uspto-grants-2006_04
Patent number
US07022689B2

Reaction notes

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