Ethanol hydrochloride → HCID 22219494, compound

HRID 1793939Notes

Reaction equation

HRID 1793939 reaction equation
C(OC([NH:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([CH:17]([CH3:19])[CH3:18])=[CH:13][C:12]=1[NH:20][C:21](=[O:27])[C:22]([O:24][CH2:25][CH3:26])=[O:23])=O)(C)(C)C.[ClH:28].C(O)C>C(O)C>[ClH:28].[NH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([CH:17]([CH3:19])[CH3:18])=[CH:13][C:12]=1[NH:20][C:21](=[O:27])[C:22]([O:24][CH2:25][CH3:26])=[O:23]

Participants

4

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 86595213HCID 86595213, compound

Product 1

HCID 22219494HCID 22219494, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a stirred solution of 0.266 g of ethyl [2-(2-tert-butoxycarbonylaminoethyl)-5-isopropylphenyl]oxalamate in 2 mL of ethanol was added 2 mL of 21% hydrogen chloride-ethanol solution at room temperature. After being stirred at the same temperature for 2 hours, the reaction mixture was concentrated under reduced pressure to give 0.179 g of ethyl N-[2-(2-aminoethyl)-5-isopropylphenyl]oxalamate hydrochloride.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-a2366e2f821b4357b4bad0d053c43fe0
Source dataset
uspto-grants-2006_04
Patent number
US07022689B2

Reaction notes

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