HCID 2756143, compound → HCID 69140874, compound

HRID 1794073Notes

Reaction equation

HRID 1794073 reaction equation
[CH:1]1[C:13]2[CH:12]([CH2:14][O:15][C:16]([N:18]3[CH2:23][CH2:22][N:21]([C:24]([O:26][CH2:27][C:28]4[CH:33]=[CH:32][C:31]([O:34][CH2:35][C:36]5[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=5)=[CH:30][CH:29]=4)=[O:25])[CH2:20][CH2:19]3)=[O:17])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[F:42]C1C=CC(COC2C=CC(COC(=O)OC(Cl)C)=CC=2)=CC=1.C(N1CCNCC1)(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O>>[F:42][C:39]1[CH:38]=[CH:37][C:36]([CH2:35][O:34][C:31]2[CH:30]=[CH:29][C:28]([CH2:27][O:26][C:24]([N:21]3[CH2:20][CH2:19][N:18]([C:16]([O:15][CH2:14][CH:12]4[C:11]5[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=5[C:5]5[C:13]4=[CH:1][CH:2]=[CH:3][CH:4]=5)=[O:17])[CH2:23][CH2:22]3)=[O:25])=[CH:33][CH:32]=2)=[CH:41][CH:40]=1

Participants

4

Reactant 3

HCID 2756143HCID 2756143, compoundHCID 69140720HCID 69140720, compoundHCID 86585996HCID 86585996, compound

Product 1

HCID 69140874HCID 69140874, compound

Procedure

Prepared in analogy to piperazine-1,4-dicarboxylic acid 4-benzyloxy-benzyl ester 9H-fluoren-9-ylmethyl ester (Example 41) from (RS)-carbonic acid 1-chloro-ethyl ester 4-(4-fluoro-benzyloxy)-benzyl ester) and N-Fmoc-piperazine: yellow solid. 1H-NMR (CDCl3): 3.3–3.6 m, 8H; 4.23 t, J=6 Hz, 1H; 4.48 d, J=6 Hz, 2H; 5.03 s, 2H; 5.08 s, 2H; 6.95 d, J=8.5 Hz, 2H, 7.08 t, J=8.5 Hz, 2H, 7.25–7.46 m, 8H, 7.55 d, J=7 Hz, 2H and 7.77 d, J=7 Hz, 2H.

Sources & evidence

ORD record
ord-eb7030f76c4248f1ba5426b4d623ed89
Source dataset
uspto-grants-2006_04
Patent number
US07022707B2

Reaction notes

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