Morpholine → HCID 69141588, compound

HRID 1794075Notes

Reaction equation

HRID 1794075 reaction equation
N1CCOCC1.[CH3:7][O:8][C:9]1[CH:24]=[CH:23][C:12]([CH2:13][O:14][C:15]([N:17]2[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)=[O:16])=[CH:11][CH:10]=1.[ClH:25].CCOCC>CCOCC>[ClH:25].[CH3:7][O:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:13][O:14][C:15]([N:17]2[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]2)=[O:16])=[CH:23][CH:24]=1

Participants

5

Reactant 3

HCID 8083MorpholineHCID 10953452Ether hydrochlorideHCID 22600025(4-Methoxyphenyl)methyl piperazine-1-carboxylate

Product 1

HCID 69141588HCID 69141588, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Deprotection with morpholine led to piperazine-1-carboxylic acid 4-methoxy-benzyl ester. The hydrochloride was prepared by addition of HCl/Et2O to a solution of the free base in Et2O followed by evaporation. 1H-NMR (d6-DMSO): 3.10 m, 4H and 3.60 m, 4H, piperazine-H; 5.02 s, 2H. MS (ISP): 251.2 MH+.

Workup

  1. customfollowed by evaporation
  2. custom5.02 s, 2H

Sources & evidence

ORD record
ord-6fd7ba4ba4054e618e97357e15865320
Source dataset
uspto-grants-2006_04
Patent number
US07022707B2

Reaction notes

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