Tert-butyl 4-(chlorocarbonyl)piperazine-1-carboxylate → HCID 86585997, compound

HRID 1794077Notes

Reaction equation

HRID 1794077 reaction equation
C(OC(N1CCN([C:14]([Cl:16])=[O:15])CC1)=O)(C)(C)C.[C:17]([O:21][C:22]([N:24]1[C@H:29]([CH3:30])[CH2:28][NH:27][CH2:26][C@@H:25]1[CH3:31])=[O:23])([CH3:20])([CH3:19])[CH3:18]>>[C:17]([O:21][C:22]([N:24]1[C@H:29]([CH3:30])[CH2:28][N:27]([C:14]([Cl:16])=[O:15])[CH2:26][C@@H:25]1[CH3:31])=[O:23])([CH3:20])([CH3:18])[CH3:19]

Participants

3

Reactant 2

HCID 11334154Tert-butyl 4-(chlorocarbonyl)piperazine-1-carboxylateHCID 21021901tert-Butyl (2R,6S)-2,6-dimethylpiperazine-1-carboxylate

Product 1

HCID 86585997HCID 86585997, compound

Procedure

cis-4-chlorocarbonyl-2,6-dimethyl-piperazine-1-carboxylic acid tert-butyl ester was prepared in analogy to 4-chlorocarbonyl-piperazine-1-carboxylic acid tert-butyl ester from cis-2,6-dimethylpiperazine-1-carboxylic acid tert-butyl ester (A. Muehlebach, P. Pino, Helv. Chim. Acta 73, 839 (1990)) by a modified procedure of Rhone-Poulenc DE 25 50 111 (Rhone-Poulenc).

Sources & evidence

ORD record
ord-41fc49f75aca4d0caca7af49448107a0
Source dataset
uspto-grants-2006_04
Patent number
US07022707B2

Reaction notes

Loading…