(4-Bromo-2-fluorophenyl)methanol → HCID 69142871, compound

HRID 1794106Notes

Reaction equation

HRID 1794106 reaction equation
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[C:4]([F:10])[CH:3]=1.[Cl:11][C:12]([N:14]1[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]1)=[O:13]>>[ClH:11].[N:14]1([C:12]([O:7][CH2:6][C:5]2[CH:8]=[CH:9][C:2]([Br:1])=[CH:3][C:4]=2[F:10])=[O:13])[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 2734027(4-Bromo-2-fluorophenyl)methanolHCID 11334154Tert-butyl 4-(chlorocarbonyl)piperazine-1-carboxylate

Product 1

HCID 69142871HCID 69142871, compound

Procedure

4-Bromo-2-fluorobenzyl piperazine-1-carboxylate hydrochloride was prepared from 4-bromo-2-fluorobenzyl alcohol and 1-chlorocarbonyl-4-tert-butoxycarbonylpiperazine according to the methods described for Examples 52 and 54 to give the product as a white solid (26.5%); melting point 209.5–209.6° C.; NMR δH (400 MHz, DMSO-d6) 3.078(4H, bt), 3.594(4H, bt), 5.118(2H, s), 7.455(2H, m), 7.592(1H, m) and 9.147(2H, bs).

Sources & evidence

ORD record
ord-c9d75501718e41dab28c219b1d5acd3e
Source dataset
uspto-grants-2006_04
Patent number
US07022707B2

Reaction notes

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