(4-Bromo-2-fluorophenyl)methanol → HCID 69142871, compound

Participants

Reaction Steps

4-Bromo-2-fluorobenzyl piperazine-1-carboxylate hydrochloride was prepared from 4-bromo-2-fluorobenzyl alcohol and 1-chlorocarbonyl-4-tert-butoxycarbonylpiperazine according to the methods described for Examples 52 and 54 to give the product as a white solid (26.5%); melting point 209.5–209.6° C.; NMR δH (400 MHz, DMSO-d6) 3.078(4H, bt), 3.594(4H, bt), 5.118(2H, s), 7.455(2H, m), 7.592(1H, m) and 9.147(2H, bs).

Provenance & Evidence