反应详情

2,6-Difluoro-4-(3-fluorobenzyl)oxybenzyl cis-2,6-dimethylpiperazine-1-carboxylate was prepared from 2,6-difluoro-4-hydroxybenzyl alcohol, 3-fluorobenzyl chloride and 1-chlorocarbonyl-2,6-dimethyl-4-tert-butoxycarbonylpiperazine according to the methods described for Example 54 and 121 to give the product as a yellow oil: δH (400 MHz; d6-DMSO) 1.13 (6H, d, J 7.0 Hz), 2.60 (2H, dd, J 12, 4.5 Hz), 2.66 (2H, d, J 12 Hz), 3.77–3.86 (2H, m), 5.03 (2H, s), 5.18 (2H, s), 6.84–6.93 (2H, m), 7.16–7.22 (1H, m), 7.27–7.32 (2H, m) and 7.42–7.49 (1H, m); HPLC (XTERRA, 50–80%, 220 nm) 99.8% (5.96 min).