Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Fluorobenzyl chloride → 2,6-Difluoro-4-(3-fluorobenzyl)oxybenzyl cis-2,6-dimethylpiperazine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Fluorobenzyl chloride | HCID 9974 | — |
| 반응물 | rac-tert-butyl (3R,5S)-4-(carboxy)-3,5-dimethylpiperazine-1-carboxylate | HCID 22219933 | — |
| 반응물 | 3,5-Difluoro-4-(hydroxymethyl)phenol | HCID 22219975 | — |
| 생성물 | 2,6-Difluoro-4-(3-fluorobenzyl)oxybenzyl cis-2,6-dimethylpiperazine-1-carboxylate | HCID 69142679 | — |
반응 단계
2,6-Difluoro-4-(3-fluorobenzyl)oxybenzyl cis-2,6-dimethylpiperazine-1-carboxylate was prepared from 2,6-difluoro-4-hydroxybenzyl alcohol, 3-fluorobenzyl chloride and 1-chlorocarbonyl-2,6-dimethyl-4-tert-butoxycarbonylpiperazine according to the methods described for Example 54 and 121 to give the product as a yellow oil: δH (400 MHz; d6-DMSO) 1.13 (6H, d, J 7.0 Hz), 2.60 (2H, dd, J 12, 4.5 Hz), 2.66 (2H, d, J 12 Hz), 3.77–3.86 (2H, m), 5.03 (2H, s), 5.18 (2H, s), 6.84–6.93 (2H, m), 7.16–7.22 (1H, m), 7.27–7.32 (2H, m) and 7.42–7.49 (1H, m); HPLC (XTERRA, 50–80%, 220 nm) 99.8% (5.96 min).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07022707B2 |
| 출처 데이터셋 | uspto-grants-2006_04 |
| ORD ID | ord-f3996aff3ee74aba9b543069427796ae |
| 출처 메모 | uspto-grants-2006_04 |