2-Thiopheneethanol → HCID 69141364, compound

HRID 1794131Notes

Reaction equation

[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][OH:8].[F:9][C:10]1[CH:17]=[CH:16][C:15](O)=[CH:14][C:11]=1[CH2:12][OH:13]>>[F:9][C:10]1[CH:17]=[CH:16][C:15]([O:8][CH2:7][CH2:6][C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)=[CH:14][C:11]=1[CH2:12][OH:13]

Participants

Reactant 2

HCID 794002-Thiopheneethanol

HCID 691416144-Fluoro-3-(hydroxymethyl)phenol

Product 1

HCID 69141364HCID 69141364, compound

Procedure

2-Fluoro-5-[2-(2-thienyl)]ethoxybenzyl alcohol was prepared from 2-thiophene-ethanol (0.5 g) and 2-fluoro-5-hydroxybenzyl alcohol according to the procedure described in Example 152 to give the product as a clear oil (0.12 g); δH (400 MHz, CDCl3) 7.16 (1H, dd, J 5, 1.5 Hz), 6.98–6.92 (3H, m), 6.91 (1H, m), 6.78 (1H, dt, J 9, 3.5 Hz), 4.70 (2H, d, J 6 Hz), 4.15 (2H, t, J 6.5 Hz) and 3.28 (2H, dt, J 6.5, 1 Hz); HPLC (XTERRA, 50/80%, 220 nm) 97% (3.49 min).

Sources & evidence

ORD record: ord-ac4382ab526b4160a821c9fb21462748
Source dataset: uspto-grants-2006_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07022707B2

Reaction notes

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