HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Difluorobenzyl alcohol → (R)-2-Ethyl-piperazine-1-carboxylic acid 2,6-difluoro-benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Difluorobenzyl alcohol | HCID 87921 | — |
| Reactant | (R)-2-ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(2,6-difluoro-benzyl) ester | HCID 69143773 | — |
| Reactant | (R)-4-Chlorocarbonyl-3-ethyl-piperazine-1-carboxylic acid tert-butyl ester | HCID 86586001 | — |
| Product | (R)-2-Ethyl-piperazine-1-carboxylic acid 2,6-difluoro-benzyl ester | HCID 69142116 | — |
Reaction Steps
This compound was prepared from (R)-4-chlorocarbonyl-3-ethyl-piperazine-1-carboxylic acid tert-butyl ester and 2,6-difluorobenzylalcohol via (R)-2-ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(2,6-difluoro-benzyl) ester according to the procedures described in Example 177 to give the product as a yellowish oil (69 mg); MS (ISP): 285.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07022707B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-61a31937fed9427dae4fe0fb23664c94 |
| Source note | uspto-grants-2006_04 |