4-(Chloromethyl)-2-methyl-1,3-thiazole → 2,6-Difluoro-4-[(2-methyl-4-thiazolyl)methoxy]benzenemethanol

HRID 1794148Notes

Reaction equation

HRID 1794148 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[C:6]([F:10])[C:7]=1[CH2:8][OH:9].Cl[CH2:13][C:14]1[N:15]=[C:16]([CH3:19])[S:17][CH:18]=1>>[F:1][C:2]1[CH:3]=[C:4]([O:11][CH2:13][C:14]2[N:15]=[C:16]([CH3:19])[S:17][CH:18]=2)[CH:5]=[C:6]([F:10])[C:7]=1[CH2:8][OH:9]

Participants

3

Reactant 2

HCID 7363414-(Chloromethyl)-2-methyl-1,3-thiazoleHCID 222199753,5-Difluoro-4-(hydroxymethyl)phenol

Product 1

HCID 222199552,6-Difluoro-4-[(2-methyl-4-thiazolyl)methoxy]benzenemethanolYield 73%

Procedure

This compound was prepared from 3,5-difluoro-4-hydroxymethyl-phenol and 4-chlormethyl-2-methylthiazol according to the procedure described in Example 179 to give the product as a colorless oil (369 mg, 73%); MS (ISP): 272.3 (M+H)+.

Sources & evidence

ORD record
ord-d1e7f5499b5c414ebae3b44093005352
Source dataset
uspto-grants-2006_04
Patent number
US07022707B2

Reaction notes

Loading…