3-Methoxypropyl 4-methylbenzenesulfonate → HCID 69140635, compound

HRID 1794154Notes

Reaction equation

HRID 1794154 reaction equation
[F:1][C:2]1[CH:26]=[CH:25][C:24]([OH:27])=[CH:23][C:3]=1[CH2:4][O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10][C@H:9]1[CH2:21][CH3:22])=[O:7].[CH3:28][O:29][CH2:30][CH2:31][CH2:32]OS(C1C=CC(C)=CC=1)(=O)=O>>[F:1][C:2]1[CH:26]=[CH:25][C:24]([O:27][CH2:32][CH2:31][CH2:30][O:29][CH3:28])=[CH:23][C:3]=1[CH2:4][O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10][C@H:9]1[CH2:21][CH3:22])=[O:7]

Participants

3

Reactant 2

HCID 135229883-Methoxypropyl 4-methylbenzenesulfonateHCID 69141315HCID 69141315, compound

Product 1

HCID 69140635HCID 69140635, compoundYield 94%

Procedure

This compound was prepared from (R)-2-ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(2-fluoro-5-hydroxy-benzyl) ester and toluene-4-sulfonic acid 3-methoxy-propyl ester according to the procedure described in Example 187 to give the product as a colorless oil (342 mg; 94%); MS (ISP): 472.4 (M+NH4)+.

Sources & evidence

ORD record
ord-c16d5d61c34d44b89e0a42087ff3a134
Source dataset
uspto-grants-2006_04
Patent number
US07022707B2

Reaction notes

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