HCID 22220080, compound → HCID 69141168, compound

HRID 1794163Notes

Reaction equation

HRID 1794163 reaction equation
[CH2:1]([O:4][C:5]1[CH:12]=[C:11]([F:13])[C:8]([CH2:9][OH:10])=[C:7]([Cl:14])[CH:6]=1)[CH:2]=[CH2:3].[C:15]([O:19][C:20]([N:22]1[CH2:27][CH2:26][N:25]([C:28](Cl)=[O:29])[C@H:24]([CH2:31][CH3:32])[CH2:23]1)=[O:21])([CH3:18])([CH3:17])[CH3:16]>>[CH2:1]([O:4][C:5]1[CH:12]=[C:11]([F:13])[C:8]([CH2:9][O:10][C:28]([N:25]2[CH2:26][CH2:27][N:22]([C:20]([O:19][C:15]([CH3:17])([CH3:16])[CH3:18])=[O:21])[CH2:23][C@H:24]2[CH2:31][CH3:32])=[O:29])=[C:7]([Cl:14])[CH:6]=1)[CH:2]=[CH2:3]

Participants

3

Reactant 2

HCID 22220080HCID 22220080, compoundHCID 86586001(R)-4-Chlorocarbonyl-3-ethyl-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 69141168HCID 69141168, compoundYield 87%

Procedure

This compound was prepared from 4-allyloxy-2-chloro-6-fluoro-benzylalcohol and (R)-4-chlorocarbonyl-3-ethyl-piperazine-1-carboxylic acid tert-butyl ester according to the procedure described in Example 179 to give the product as a colorless oil (405 mg; 87%); MS (ISP): 474.4 (M+NH4)+.

Sources & evidence

ORD record
ord-62b06560a73f46cd914cfe75367bf2e8
Source dataset
uspto-grants-2006_04
Patent number
US07022707B2

Reaction notes

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