反应详情

200 g (0.98 mole) of 2-(4-methoxyphenyl)-cyclohexanone from stage 2 and 91 g (1 mole) of dimethylammonium ethylene chloride were stirred in 1000 ml of dry acetonitrile at room temperature. After addition of 1 ml of acetyl chloride the reaction mixture was stirred for a further 3 hours at room temperature, a colourless, clear solution being formed. 2000 ml of dry ether were then added dropwise to the reaction mixture and the hydrochloride crystallised out. 160 g (56% of theory) of colourless crystals were obtained. The base was freed from the hydrochloride with dichloromethane/sodium hydroxide and, after drying the solution, the dichloromethane was removed by distillation.

1. customa colourless, clear solution being formed
2. customthe hydrochloride crystallised out
3. custom160 g (56% of theory) of colourless crystals were obtained
4. customafter drying the solution
5. customthe dichloromethane was removed by distillation