Methylamine → HCID 10432314, compound

HRID 1794280Notes

Reaction equation

HRID 1794280 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:16]=[C:15]3[C:11]([CH2:12][N:13]4[C:19]([C:20]5[C:21]([C:26]6[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=6)=[N:22][O:23][C:24]=5[CH3:25])=[N:18][N:17]=[C:14]43)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[CH3:32][NH2:33]>O>[CH3:32][NH:33][C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:16]=[C:15]3[C:11]([CH2:12][N:13]4[C:19]([C:20]5[C:21]([C:26]6[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=6)=[N:22][O:23][C:24]=5[CH3:25])=[N:18][N:17]=[C:14]43)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 86591497HCID 86591497, compound

Product 1

HCID 10432314HCID 10432314, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

8-(6-Chloropyridazin-3-yl)-3-(5-methyl-3-phenylisoxazol-4-yl)-5H-[1,2,4]triazolo[3,4-α]isoindole was heated in a sealed tube with methylamine (3 ml of 40% solution in water) for 16 h. The reaction mixture was cooled, poured into H2O and extracted into CH2Cl2, dried (MgSO4), and concentrated under reduced pressure.

Workup

  1. temperatureThe reaction mixture was cooled
  2. extractionextracted into CH2Cl2
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-829774e902fe48ec9881b7652a0b99af
Source dataset
uspto-grants-2006_04
Patent number
US07022724B2

Reaction notes

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