Hydrochloric Acid → HCID 69560524, compound

HRID 1794361Notes

Reaction equation

HRID 1794361 reaction equation
[C:1]1([C:7]2[O:11][N:10]=[CH:9][C:8]=2/[CH:12]=[CH:13]/[C:14]([O:16]CC)=[O:15])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl>C(O)(=O)C>[C:1]1([C:7]2[O:11][N:10]=[CH:9][C:8]=2/[CH:12]=[CH:13]/[C:14]([OH:16])=[O:15])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86591380HCID 86591380, compound

Product 1

HCID 69560524HCID 69560524, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of ethyl (E)-3-(5-phenyl-4-isoxazolyl)propenoate (4.89 g), 2N hydrochloric acid (50 ml) and acetic acid (50 ml) was refluxed for 3 hr. The reaction mixture was concentrated, and water was added to the residue. The obtained colorless crystals were filtrated to give (E)-3-(5-phenyl-4-isoxazolyl)propenoic acid (4.02 g, yield 93%). The crystals were recrystallized from acetone-hexane. melting point: 197–199° C.

Workup

  1. temperaturewas refluxed for 3 hr
  2. concentrationThe reaction mixture was concentrated
  3. additionwater was added to the residue
  4. filtrationThe obtained colorless crystals were filtrated

Sources & evidence

ORD record
ord-70616c83e77d48509f1179ee37a7d4df
Source dataset
uspto-grants-2006_04
Patent number
US07022725B2

Reaction notes

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