反应详情

温度

100 °C

N-(5-Bromo-4-methyl-2-propylimidazol-1-yl)-2-ethoxybenzamide from Example 2a (0.5 g, 1.2 mmol) and copper(I) cyanide (0.3 g, 3.5 mmol) are introduced into 12.5 ml of pyridine and heated at 100° C. for 6 hours. Potassium iodide (23 mg, 0.56 mmol) is added to the mixture, which is then stirred for a further 6 hours at 100° C. The reaction mixture is cooled to room temperature and, after addition of 50 ml of ethyl acetate, washed with dilute alkaline H2O2 solution. The aqueous phase is re-extracted with ethyl acetate, and the combined ethyl acetate phase is concentrated, finally azeotroped with toluene and again concentrated.

1. temperatureThe reaction mixture is cooled to room temperature
2. washwashed
3. additionwith dilute alkaline H2O2 solution
4. extractionThe aqueous phase is re-extracted with ethyl acetate
5. concentrationthe combined ethyl acetate phase is concentrated
6. customfinally azeotroped with toluene
7. concentrationagain concentrated