Trifluoroacetic acid → HCID 22222315, compound

HRID 1794602Notes

Reaction equation

HRID 1794602 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][N:11]([CH:21]([C:24]1[N:25]([CH2:38][C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)[C:26](=[O:37])[C:27]2[C:32]([C:33]([F:36])([F:35])[F:34])=[N:31][O:30][C:28]=2[N:29]=1)[CH2:22][CH3:23])[C:12](=[O:20])[C:13]1[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:7][CH2:8][CH2:9][CH2:10][N:11]([CH:21]([C:24]1[N:25]([CH2:38][C:39]2[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=2)[C:26](=[O:37])[C:27]2[C:32]([C:33]([F:36])([F:35])[F:34])=[N:31][O:30][C:28]=2[N:29]=1)[CH2:22][CH3:23])[C:12](=[O:20])[C:13]1[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 21022367HCID 21022367, compound

Product 1

HCID 22222315HCID 22222315, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 12 (52 mg, 0.083 mmol) in CH2Cl2 (4.0 mL) stirred at room temperature was added TFA (1.0 mL). The reaction mixture was stirred at room temperature for 30 min. Solvent was removed in vacuo, the residue was purified by preparative HPLC to give 13 as a white solid (42 mg, 96%). MS (ESI): 528 (M+H)+.

Workup

  1. customSolvent was removed in vacuo
  2. customthe residue was purified by preparative HPLC

Sources & evidence

ORD record
ord-84931abe17874348b94f250d7e1fd492
Source dataset
uspto-grants-2006_04
Patent number
US07022850B2

Reaction notes

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