2-Fluoro-4,5-dimethoxybenzaldehyde → 2-Tert-butoxycarbonylamino-3-(2-fluoro-4,5-dimethoxy-phenyl)-acrylic acid ethyl ester

HRID 1794648Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1794648
[F:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[C:7]([O:12][CH3:13])=[CH:6][C:3]=1[CH:4]=O.[CH2:14]([O:16][C:17](=[O:33])[CH:18]([NH:25][C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])P(OC)(OC)=O)[CH3:15]>>[CH2:14]([O:16][C:17](=[O:33])[C:18]([NH:25][C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])=[CH:4][C:3]1[CH:6]=[C:7]([O:12][CH3:13])[C:8]([O:10][CH3:11])=[CH:9][C:2]=1[F:1])[CH3:15]

Komponenten

3

Edukt 2

HCID 6035952-Fluoro-4,5-dimethoxybenzaldehydeHCID 45073912Ethyl 2-((tert-Butoxycarbonyl)amino)-2-(dimethoxyphosphoryl)acetate

Produkt 1

HCID 695948282-Tert-butoxycarbonylamino-3-(2-fluoro-4,5-dimethoxy-phenyl)-acrylic acid ethyl ester

Versuchsvorschrift

In a preferred method of preparing F-Dopa, 2-fluoro-4,5-dimethoxybenzaldehyde is reacted with tert-Butoxycarbonylamino-(dimethoxy-phosphoryl)-acetic acid ethyl ester to produce 2-tert-butoxycarbonylamino-3-(2-fluoro-4,5-dimethoxy-phenyl)-acrylic acid ethyl ester. In this method R is methyl, R1 is methoxy, X is fluorine, R2 is methyl, and Y is tert-butoxycarbonyl.

Quellen und Nachweise

ORD-Eintrag
ord-9afb19bd77ab412f98c8a9159dc97d2c
Quelldatensatz
uspto-grants-2006_04
Patentnummer
US07022872B2

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