HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoro-4,5-dimethoxybenzaldehyde → 2-Tert-butoxycarbonylamino-3-(2-fluoro-4,5-dimethoxy-phenyl)-acrylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoro-4,5-dimethoxybenzaldehyde | HCID 603595 | — |
| Reactant | Ethyl 2-((tert-Butoxycarbonyl)amino)-2-(dimethoxyphosphoryl)acetate | HCID 45073912 | — |
| Product | 2-Tert-butoxycarbonylamino-3-(2-fluoro-4,5-dimethoxy-phenyl)-acrylic acid ethyl ester | HCID 69594828 | — |
Reaction Steps
In a preferred method of preparing F-Dopa, 2-fluoro-4,5-dimethoxybenzaldehyde is reacted with tert-Butoxycarbonylamino-(dimethoxy-phosphoryl)-acetic acid ethyl ester to produce 2-tert-butoxycarbonylamino-3-(2-fluoro-4,5-dimethoxy-phenyl)-acrylic acid ethyl ester. In this method R is methyl, R1 is methoxy, X is fluorine, R2 is methyl, and Y is tert-butoxycarbonyl.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07022872B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-9afb19bd77ab412f98c8a9159dc97d2c |
| Source note | uspto-grants-2006_04 |