Sertraline → Sertraline Hydrochloride

HRID 1794670Notes

Reaction equation

HRID 1794670 reaction equation
[CH3:1][NH:2][C@@H:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]([C:13]2[CH:14]=[CH:15][C:16]([Cl:20])=[C:17]([Cl:19])[CH:18]=2)[CH2:5][CH2:4]1>C1(C)C=CC=CC=1>[CH3:1][NH:2][C@@H:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]([C:13]2[CH:14]=[CH:15][C:16]([Cl:20])=[C:17]([Cl:19])[CH:18]=2)[CH2:5][CH2:4]1.[ClH:19]

Participants

3

Reactant 1

HCID 68617Sertraline

Product 1

HCID 63009Sertraline HydrochlorideYield 203.7%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Sertraline base (5.8 gr.) was dissolved in toluene (200 mL). HCl gas was bubbled (about pH 1.5) through the solution. A gel is formed. Filtration and drying at 50° C. for 16 hours gives amorphous sertraline hydrochloride (6.61 gr.).

Workup

  1. customHCl gas was bubbled (about pH 1.5) through the solution
  2. customA gel is formed
  3. filtrationFiltration
  4. customdrying at 50° C. for 16 hours

Sources & evidence

ORD record
ord-b67100a65e784915a1fc9a728d03c047
Source dataset
uspto-grants-2006_04
Patent number
US07022881B2

Reaction notes

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