反应详情

A solution of triethylamine (27 mg) in methylene chloride (0.5 ml) was added to a solution of methyl 2,3-dibromo-4-(3,4-dimethoxyphenyl)-4-oxobutanoate (49 mg, 0.1 mmol), prepared above, in methylene chloride (0.5 ml). The mixture was stirred at room temperature for 15 min and then heated under reflux with stirring for 2 hr. The mixture was then treated by a conventional method, and the crude product was purified by column chromatography on silica gel (hexane/ethyl acetate) to give the title compound as a yellow crystal (21 mg, 71%).

1. temperatureheated
2. temperatureunder reflux
3. stirringwith stirring for 2 hr
4. additionThe mixture was then treated by a conventional method
5. customthe crude product was purified by column chromatography on silica gel (hexane/ethyl acetate)