Ammonia → HCID 69654860, compound

HRID 1794769Notes

Reaction equation

HRID 1794769 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:13]=[C:12]([C@@H:14]3[CH2:16][O:15]3)[O:11][N:10]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].[NH3:17]>CO>[NH2:17][CH2:16][C@@H:14]([C:12]1[O:11][N:10]=[C:9]([C:4]2[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=2)[CH:13]=1)[OH:15]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86584556HCID 86584556, compound

Product 1

HCID 69654860HCID 69654860, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared from 3-(3,4-dichlorophenyl)-5-[(2S)-oxiran-2-yl]isoxazole (which was obtained in Example 108), in methyl alcohol and ammonia in substantially the same manner as described in Example 105, and was obtained as a white solid (0.43 g, 80% yield), mp 105° C.; MS (ES) m/z: 273 (MH+); 1H NMR (400 MHz, CDCl3) δ 3.18 (m, 2H), 4.83 (m, 1H), 6.56 (s, 1H),7.54 (d, 1H), 7.62 (d, 1H), 7.90 (s, 1H).

Sources & evidence

ORD record
ord-9e531b94028a49eb95a62add9cb1fb15
Source dataset
uspto-grants-2006_04
Patent number
US07022716B2

Reaction notes

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