(R)-2-(tetrazolo[1,5-a]pyrid 6-yl)oxirane → (1R)-2-Amino-1-[1,2,3,4]tetraazolo[1,5-a]pyridin-6-yl-1-ethanol

Participants

Role	Name	HCID	Charge
Reactant	(R)-2-(tetrazolo[1,5-a]pyrid 6-yl)oxirane	HCID 13090314	—
Reactant	Ammonium methanol	HCID 22220579	—
Product	(1R)-2-Amino-1-[1,2,3,4]tetraazolo[1,5-a]pyridin-6-yl-1-ethanol	HCID 69654686	—

Reaction Steps

The title compound was prepared from 6-[(2R)oxiranyl][1,2,3,4]tetraazolo[1,5-a]pyridine and saturated ammonium methanol in substantially the same manner, as described in Example 124. The product was obtained as an off-white solid; mp 153–154° C.; 1H NMR (400 MHz, DMSO-d6) δ 1.60 (brs, 2 H), 2.73–2.84 (m, 2 H), 4.65–4.68 (m, 1 H), 5.70 (brs, 1 H), 7.83–7.87 (m, 1 H), 8.14–8.16 (m, 1 H), 9.08–9.09 (m, 1 H); MS (ES) m/z: 180 (M+H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07022716B2
Source dataset	uspto-grants-2006_04
ORD ID	ord-5eb8f760d2194968b3999185946825dd
Source note	uspto-grants-2006_04