Isoamyl Nitrite → HCID 21847964, compound

HRID 1794991Notes

Reaction equation

HRID 1794991 reaction equation
[NH2:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.[N:7]([O-])=O.[Na+].C(ON=O)C[CH:13]([CH3:15])C>>[N:1]1[C:2]2=[CH:6][CH:5]=[N:4][N:3]2[CH:15]=[CH:13][N:7]=1

Participants

4

Reactant 3

HCID 8053Isoamyl NitriteHCID 23668193Sodium NitriteHCID 178418806HCID 178418806, compound

Product 1

HCID 21847964HCID 21847964, compound

Procedure

The method of Ege and Gilbert, J. Het. Chem. 1981, 18, 675-677, is used to prepare the desired ring system (Scheme 4). Thus, aminopyrazole 4-A is converted to diazonium salt 4-B, using sodium nitrite/acid or such reagents as isoamylnitrite. The diazonium salt is condensed with a phosphorus ylide compound 4-C to give the pyrazolo[5,1-c][1,2,4]triazine product.

Workup

  1. customto prepare the desired ring system (Scheme 4)

Sources & evidence

ORD record
ord-71d662d1eb7a4257b2b71a38db4381aa
Source dataset
uspto-grants-2006_04
Patent number
US07026317B2

Reaction notes

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