Isoamyl Nitrite → HCID 21847964, compound

Participants

Reaction Steps

The method of Ege and Gilbert, J. Het. Chem. 1981, 18, 675-677, is used to prepare the desired ring system (Scheme 4). Thus, aminopyrazole 4-A is converted to diazonium salt 4-B, using sodium nitrite/acid or such reagents as isoamylnitrite. The diazonium salt is condensed with a phosphorus ylide compound 4-C to give the pyrazolo[5,1-c][1,2,4]triazine product.

Provenance & Evidence