反应详情

5-[3,5-Bis(trifluoromethyl)benzyl]-6-oxo-7-phenyl-2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocine (compound of Reference Example 5; 729 mg) was dissolved in methylene chloride (10 mL). To the resulting solution, 3-chloroperbenzoic acid (524 mg) was added, and then the mixture was stirred at room temperature for 24 hours. The reaction mixture was purified on a silica gel column chromatography (ethyl acetate:methanol=5:1) to obtain 5-[3,5-bis(trifluoromethyl)benzyl]-6-oxo-7-phenyl-2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocine 10-oxide (411 mg, 54%).

1. customThe reaction mixture was purified on a silica gel column chromatography (ethyl acetate:methanol=5:1)