Hydrochloric Acid → HCID 178499561, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4-imidazoleacetic acid (4.2 g, 26 mmol) in methanol (150 mL) is treated with HCl in dioxane (5 mL). The mixture is heated at 60° C. overnight. The solution is evaporated to give a white solid, which is then recrystallized from ether/hexane to yield 4-imidazoleacetic acid methyl ester hydrochloride. The yield is 4.5 g, 98%.

Provenance & Evidence