Hydrochloric Acid → HCID 178499561, compound

HRID 1795105Notes

Reaction equation

HRID 1795105 reaction equation
[NH:1]1[CH:5]=[C:4]([CH2:6][C:7]([OH:9])=[O:8])[N:3]=[CH:2]1.[ClH:10].[CH3:11]O>O1CCOCC1>[ClH:10].[CH3:11][O:8][C:7](=[O:9])[CH2:6][C:4]1[N:3]=[CH:2][NH:1][CH:5]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 96215Imidazole-4-acetic acid

Product 1

HCID 178499561HCID 178499561, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
60 °C

Procedure

A solution of 4-imidazoleacetic acid (4.2 g, 26 mmol) in methanol (150 mL) is treated with HCl in dioxane (5 mL). The mixture is heated at 60° C. overnight. The solution is evaporated to give a white solid, which is then recrystallized from ether/hexane to yield 4-imidazoleacetic acid methyl ester hydrochloride. The yield is 4.5 g, 98%.

Workup

  1. customThe solution is evaporated
  2. customto give a white solid, which
  3. customis then recrystallized from ether/hexane

Sources & evidence

ORD record
ord-3d6c47c738b349f087ae39cdaede9abe
Source dataset
uspto-grants-2006_04
Patent number
US07026339B2

Reaction notes

Loading…