Hydrazine hydrate (1:1) → HCID 69595470, compound

HRID 1795119Notes

Reaction equation

HRID 1795119 reaction equation
[CH:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]([CH3:23])[S:10]([C:13]1[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=1)(=[O:12])=[O:11])=O.O.[NH2:25][NH2:26]>C(O)C>[N:25](=[CH:1][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]([CH3:23])[S:10]([C:13]1[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=1)(=[O:12])=[O:11])[NH2:26]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 22185718HCID 22185718, compound

Product 1

HCID 69595470HCID 69595470, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of N-(2-formylphenyl)-N-methyl-4-(trifluoromethyl)benzenesulfonamide (0.40 g, 1.2 mmol) in ethanol (13 mL) is treated with hydrazine monohydrate (69 □L, 1.6 mmol). The reaction is stirred at rt overnight. The reaction is concentrated, taken up in ether-hexane, filtered and evaporated. An 87% yield (0.37 g) of N{2-[hydrazonomethyl]phenyl}-N-methyl-4-(trifluoromethyl)benzenesulfonamide is obtained.

Workup

  1. concentrationThe reaction is concentrated
  2. filtrationfiltered
  3. customevaporated

Sources & evidence

ORD record
ord-f1163736bd8d480ea85058bc6013edf1
Source dataset
uspto-grants-2006_04
Patent number
US07026339B2

Reaction notes

Loading…