Potassium Carbonate → [(6-Bromopyridin-3-yl)methyl](3,3,3-trifluoropropyl)propanedinitrile

HRID 1795137Notes

Reaction equation

HRID 1795137 reaction equation
[F:1][C:2]([F:11])([F:10])[CH2:3][CH2:4][CH:5]([C:8]#[N:9])[C:6]#[N:7].C(=O)([O-])[O-].[K+].[K+].[Br:18][C:19]1[N:24]=[CH:23][C:22]([CH2:25]Br)=[CH:21][CH:20]=1>CS(C)=O>[Br:18][C:19]1[N:24]=[CH:23][C:22]([CH2:25][C:5]([CH2:4][CH2:3][C:2]([F:10])([F:11])[F:1])([C:8]#[N:9])[C:6]#[N:7])=[CH:21][CH:20]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 64246602-Bromo-5-bromomethylpyridineHCID 221857612-(3,3,3-Trifluoropropyl)malononitrile

Product 1

HCID 22185751[(6-Bromopyridin-3-yl)methyl](3,3,3-trifluoropropyl)propanedinitrileYield 30.2%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

By using (3,3,3-trifluoropropyl)malononitrile (3.6 g), dimethylsulfoxide (20 ml), potassium carbonate (3.0 g) and 6-bromo-3-(bromomethyl)pyridine (5.5 g) according to the similar method described in Production Example 4 was obtained 2.2 g of 2-((6-bromo-3-pyridyl)methyl)-2-(3,3,3-trifluoropropyl)malononitrile represented by the following formula (hereinafter referred to as the present invention compound (10)).

Sources & evidence

ORD record
ord-102dbef8c4284dce9d47afab3c3d4b41
Source dataset
uspto-grants-2006_04
Patent number
US07026340B2

Reaction notes

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