HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → [(6-Fluoropyridin-3-yl)methyl](3,3,3-trifluoropropyl)propanedinitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-(Bromomethyl)-2-fluoropyridine | HCID 22050638 | — |
| Reactant | 2-(3,3,3-Trifluoropropyl)malononitrile | HCID 22185761 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | [(6-Fluoropyridin-3-yl)methyl](3,3,3-trifluoropropyl)propanedinitrile | HCID 22185764 | 34.5% |
Reaction Steps
By using (3,3,3-trifluoropropyl)malononitrile (5.8 g), dimethylsulfoxide (20 ml), potassium carbonate (4.8 g) and 6-fluoro-3-(bromomethyl)pyridine (6.7 g) according to the similar method described in Production Example 4 was obtained 3.3 g of 2-((6-fluoro-3-pyridyl)methyl)-2-(3,3,3-trifluoropropyl)malononitrile represented by the following formula (hereinafter referred to as the present invention compound (13)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07026340B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-1b3341647f504b419935353504dafd51 |
| Source note | uspto-grants-2006_04 |