Potassium Carbonate → [(6-Fluoropyridin-3-yl)methyl](3,3,3-trifluoropropyl)propanedinitrile

HRID 1795138Notes

Reaction equation

HRID 1795138 reaction equation
[F:1][C:2]([F:11])([F:10])[CH2:3][CH2:4][CH:5]([C:8]#[N:9])[C:6]#[N:7].C(=O)([O-])[O-].[K+].[K+].[F:18][C:19]1[N:24]=[CH:23][C:22]([CH2:25]Br)=[CH:21][CH:20]=1>CS(C)=O>[F:18][C:19]1[N:24]=[CH:23][C:22]([CH2:25][C:5]([CH2:4][CH2:3][C:2]([F:10])([F:11])[F:1])([C:8]#[N:9])[C:6]#[N:7])=[CH:21][CH:20]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 220506385-(Bromomethyl)-2-fluoropyridineHCID 221857612-(3,3,3-Trifluoropropyl)malononitrile

Product 1

HCID 22185764[(6-Fluoropyridin-3-yl)methyl](3,3,3-trifluoropropyl)propanedinitrileYield 34.5%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

By using (3,3,3-trifluoropropyl)malononitrile (5.8 g), dimethylsulfoxide (20 ml), potassium carbonate (4.8 g) and 6-fluoro-3-(bromomethyl)pyridine (6.7 g) according to the similar method described in Production Example 4 was obtained 3.3 g of 2-((6-fluoro-3-pyridyl)methyl)-2-(3,3,3-trifluoropropyl)malononitrile represented by the following formula (hereinafter referred to as the present invention compound (13)).

Sources & evidence

ORD record
ord-1b3341647f504b419935353504dafd51
Source dataset
uspto-grants-2006_04
Patent number
US07026340B2

Reaction notes

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