HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → [(6-Bromopyridin-2-yl)methyl](3,3,3-trifluoropropyl)propanedinitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Bromo-6-(bromomethyl)pyridine | HCID 12954796 | — |
| Reactant | 2-(3,3,3-Trifluoropropyl)malononitrile | HCID 22185761 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | [(6-Bromopyridin-2-yl)methyl](3,3,3-trifluoropropyl)propanedinitrile | HCID 22185765 | 69.3% |
Reaction Steps
By using (3,3,3-trifluoropropyl)malononitrile (540 mg), N,N-dimethylformamide (4 ml), potassium carbonate (400 mg) and 6-bromo-2-(bromomethyl)pyridine (590 mg) according to the similar method described in Production Example 4 was obtained 541 mg of 2-((6-bromo-2-pyridyl)methyl)-2-(3,3,3-trifluoropropyl)malononitrile represented by the following formula (hereinafter referred to as the present invention compound (14)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07026340B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-7737d0aca69741869a89fb73a66e5e09 |
| Source note | uspto-grants-2006_04 |