Potassium Carbonate → [(6-Bromopyridin-2-yl)methyl](3,3,3-trifluoropropyl)propanedinitrile

HRID 1795139Notes

Reaction equation

HRID 1795139 reaction equation
[F:1][C:2]([F:11])([F:10])[CH2:3][CH2:4][CH:5]([C:8]#[N:9])[C:6]#[N:7].C(=O)([O-])[O-].[K+].[K+].[Br:18][C:19]1[N:24]=[C:23]([CH2:25]Br)[CH:22]=[CH:21][CH:20]=1>CN(C)C=O>[Br:18][C:19]1[N:24]=[C:23]([CH2:25][C:5]([CH2:4][CH2:3][C:2]([F:10])([F:11])[F:1])([C:8]#[N:9])[C:6]#[N:7])[CH:22]=[CH:21][CH:20]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 129547962-Bromo-6-(bromomethyl)pyridineHCID 221857612-(3,3,3-Trifluoropropyl)malononitrile

Product 1

HCID 22185765[(6-Bromopyridin-2-yl)methyl](3,3,3-trifluoropropyl)propanedinitrileYield 69.3%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

By using (3,3,3-trifluoropropyl)malononitrile (540 mg), N,N-dimethylformamide (4 ml), potassium carbonate (400 mg) and 6-bromo-2-(bromomethyl)pyridine (590 mg) according to the similar method described in Production Example 4 was obtained 541 mg of 2-((6-bromo-2-pyridyl)methyl)-2-(3,3,3-trifluoropropyl)malononitrile represented by the following formula (hereinafter referred to as the present invention compound (14)).

Sources & evidence

ORD record
ord-7737d0aca69741869a89fb73a66e5e09
Source dataset
uspto-grants-2006_04
Patent number
US07026340B2

Reaction notes

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