HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → [(5,6-Dichloropyridin-3-yl)methyl](3,3,3-trifluoropropyl)propanedinitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-(Bromomethyl)-2,3-dichloropyridine | HCID 21962328 | — |
| Reactant | 2-(3,3,3-Trifluoropropyl)malononitrile | HCID 22185761 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | [(5,6-Dichloropyridin-3-yl)methyl](3,3,3-trifluoropropyl)propanedinitrile | HCID 22185756 | 73.2% |
Reaction Steps
By using (3,3,3-trifluoropropyl)malononitrile (480 mg), N,N-dimethylformamide (6 ml), potassium carbonate (420 mg) and 5,6-dichloro-3-(bromomethyl)pyridine (720 mg) according to the similar method described in Production Example 4 was obtained 698 mg of 2-((5,6-dichloro-3-pyridyl)methyl)-2-(3,3,3-trifluoropropyl)malononitrile represented by the following formula (hereinafter referred to as the present invention compound (15)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07026340B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-68a5c009511a4955ae1744e5ef0e2c84 |
| Source note | uspto-grants-2006_04 |