Potassium Carbonate → [(5,6-Dichloropyridin-3-yl)methyl](3,3,3-trifluoropropyl)propanedinitrile

HRID 1795140Notes

Reaction equation

HRID 1795140 reaction equation
[F:1][C:2]([F:11])([F:10])[CH2:3][CH2:4][CH:5]([C:8]#[N:9])[C:6]#[N:7].C(=O)([O-])[O-].[K+].[K+].[Cl:18][C:19]1[CH:20]=[C:21]([CH2:26]Br)[CH:22]=[N:23][C:24]=1[Cl:25]>CN(C)C=O>[Cl:18][C:19]1[CH:20]=[C:21]([CH2:26][C:5]([CH2:4][CH2:3][C:2]([F:10])([F:11])[F:1])([C:8]#[N:9])[C:6]#[N:7])[CH:22]=[N:23][C:24]=1[Cl:25]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 219623285-(Bromomethyl)-2,3-dichloropyridineHCID 221857612-(3,3,3-Trifluoropropyl)malononitrile

Product 1

HCID 22185756[(5,6-Dichloropyridin-3-yl)methyl](3,3,3-trifluoropropyl)propanedinitrileYield 73.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

By using (3,3,3-trifluoropropyl)malononitrile (480 mg), N,N-dimethylformamide (6 ml), potassium carbonate (420 mg) and 5,6-dichloro-3-(bromomethyl)pyridine (720 mg) according to the similar method described in Production Example 4 was obtained 698 mg of 2-((5,6-dichloro-3-pyridyl)methyl)-2-(3,3,3-trifluoropropyl)malononitrile represented by the following formula (hereinafter referred to as the present invention compound (15)).

Sources & evidence

ORD record
ord-68a5c009511a4955ae1744e5ef0e2c84
Source dataset
uspto-grants-2006_04
Patent number
US07026340B2

Reaction notes

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