Trifluoroacetic acid → HCID 22217720, compound

HRID 1795369Notes

Reaction equation

HRID 1795369 reaction equation
C([CH:5]1[NH:10][C:9]2[CH:11]=[CH:12][CH:13]=[C:14]3[CH:15]=[CH:16][CH:17]=[C:7]([C:8]=23)[S:6]1(=[O:19])=[O:18])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[S:6]1(=[O:18])(=[O:19])[C:7]2=[CH:17][CH:16]=[CH:15][C:14]3=[CH:13][CH:12]=[CH:11][C:9](=[C:8]23)[NH:10][CH2:5]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acid2×HCID 22217721HCID 22217721, compound

Product 1

HCID 22217720HCID 22217720, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.06 g of 2-tert-butyl-2,3-dihydro-naphtho[1,8-de][1,3]thiazin-1,1-dioxide is dissolved in 1 mL of dichloromethane and 0.02 mL of trifluoroacetic acid is added. Then the mixture is stirred for a total of 22 hours at reflux temperature and for 96 hours at ambient temperature, while during this period a total of 0.07 mL of trifluoroacetic acid is added. The reaction mixture is evaporated down in vacuo and purified by chromatography. Yield: 0.034 g; m.p.: 206° C.–207° C.

Workup

  1. temperatureat reflux temperature
  2. waitfor 96 hours at ambient temperature
  3. customThe reaction mixture is evaporated down in vacuo
  4. custompurified by chromatography

Sources & evidence

ORD record
ord-4e0e9996a0f047a686f036a47c9177f7
Source dataset
uspto-grants-2006_04
Patent number
US07026475B2

Reaction notes

Loading…