Boron tribromide → HCID 22217718, compound

HRID 1795374Notes

Reaction equation

HRID 1795374 reaction equation
C[O:2][C:3]1[C:4]2[C:13]3[C:12](=[CH:14][CH:15]=1)[S:11](=[O:17])(=[O:16])[CH:10]([CH3:18])[NH:9][C:8]=3[CH:7]=[CH:6][CH:5]=2.B(Br)(Br)Br>ClCCl>[OH:2][C:3]1[C:4]2[C:13]3[C:12](=[CH:14][CH:15]=1)[S:11](=[O:17])(=[O:16])[CH:10]([CH3:18])[NH:9][C:8]=3[CH:7]=[CH:6][CH:5]=2

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 222177237-Methoxy-2-methyl-2,3-dihydronaphtho[1,8-de][1,3]thiazine-1,1-dioxide

Product 1

HCID 22217718HCID 22217718, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
-78 °C

Procedure

0.6 g of 7-methoxy-2-methyl-2,3-dihydronaphtho[1,8-de][1,3]thiazine-1,1-dioxide is dissolved in 23 mL dichloromethane and the solution is cooled to −78° C. 2.3 mL of boron tribromide (1 molar solution in dichloromethane) is added dropwise. Then the mixture is stirred for 24 hours at ambient temperature. After evaporation in vacuo, the residue is purified by chromatography. Yield: 0.36 g; m.p.: 245° C.–246° C.

Workup

  1. customAfter evaporation in vacuo
  2. customthe residue is purified by chromatography

Sources & evidence

ORD record
ord-7de655299b2642c799bf36e9a4378ec0
Source dataset
uspto-grants-2006_04
Patent number
US07026475B2

Reaction notes

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