Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | 7-Methoxy-2-methyl-2,3-dihydronaphtho[1,8-de][1,3]thiazine-1,1-dioxide | HCID 22217723 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 22217718 | HCID 22217718 | — |
Reaction Steps
0.6 g of 7-methoxy-2-methyl-2,3-dihydronaphtho[1,8-de][1,3]thiazine-1,1-dioxide is dissolved in 23 mL dichloromethane and the solution is cooled to −78° C. 2.3 mL of boron tribromide (1 molar solution in dichloromethane) is added dropwise. Then the mixture is stirred for 24 hours at ambient temperature. After evaporation in vacuo, the residue is purified by chromatography. Yield: 0.36 g; m.p.: 245° C.–246° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07026475B2 |
|---|
| Source dataset | uspto-grants-2006_04 |
|---|
| ORD ID | ord-7de655299b2642c799bf36e9a4378ec0 |
|---|
| Source note | uspto-grants-2006_04 |
|---|
