HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 12084911, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | HCID 69599570 | HCID 69599570 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 12084911 | HCID 12084911 | 92% |
Reaction Steps
In tetrahydrofuran (35 mL) was dissolved (4R)-2-(benzyloxycarbonyl)amino-5-(2,4-difluorophenyl)-4-methyl-5-hydroxyoxazolidine (6.98 g) prepared in Example 16, and water (25 mL) and conc. hydrochloric acid (10 mL) were added. The mixture was processed as described in Example 13 to give the title compound (5.87 g) as pale yellow syrup in a yield of 92%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07026515B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-c71fe44ae1114e1686959862dc7d12c5 |
| Source note | uspto-grants-2006_04 |