Hydrochloric Acid → HCID 12084911, compound

HRID 1795489Notes

Reaction equation

HRID 1795489 reaction equation
C(OC(N[CH:12]1[NH:16][C@H:15]([CH3:17])[C:14]([C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:20]=2[F:26])([OH:18])[O:13]1)=O)C1C=CC=CC=1.[OH2:27].Cl>O1CCCC1>[CH2:14]([O:27][C:12]([NH:16][C@H:15]([CH3:17])[C:14]([C:19]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:20]=1[F:26])=[O:18])=[O:13])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 69599570HCID 69599570, compound

Product 1

HCID 12084911HCID 12084911, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In tetrahydrofuran (35 mL) was dissolved (4R)-2-(benzyloxycarbonyl)amino-5-(2,4-difluorophenyl)-4-methyl-5-hydroxyoxazolidine (6.98 g) prepared in Example 16, and water (25 mL) and conc. hydrochloric acid (10 mL) were added. The mixture was processed as described in Example 13 to give the title compound (5.87 g) as pale yellow syrup in a yield of 92%.

Workup

  1. additionwere added

Sources & evidence

ORD record
ord-c71fe44ae1114e1686959862dc7d12c5
Source dataset
uspto-grants-2006_04
Patent number
US07026515B2

Reaction notes

Loading…