p,p'-Dimethoxybenzhydryl alcohol → 4-(4,4'-Dimethoxybenzhydryl)-thiophenyl boronic acid

HRID 17956Notes

Reaction equation

HRID 17956 reaction equation
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([CH:7](O)[C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1.[SH:19][C:20]1C=C[C:23]([B:26]([OH:28])[OH:27])=[CH:22][CH:21]=1>CC(O)=O>[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([CH:7]([C:21]2[CH:22]=[C:23]([B:26]([OH:28])[OH:27])[S:19][CH:20]=2)[C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 69768p,p'-Dimethoxybenzhydryl alcoholHCID 44318944-Mercaptophenylboronic acid

Product 1

HCID 671206874-(4,4'-Dimethoxybenzhydryl)-thiophenyl boronic acid

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
60 °C

Procedure

4,4′-Dimethoxybenzhydrol (2.7 g, 11 mmol) and 4-mercaptophenylboronic acid (1.54 g, 10 mmol) were dissolved in 20 mL AcOH and heated at 60° C. for 1 h. Solvent was evaporated and the residue was dried under high vacuum. This material was used without further purification.

Workup

  1. customSolvent was evaporated
  2. customthe residue was dried under high vacuum
  3. customThis material was used without further purification

Sources & evidence

ORD record
ord-de4daeb7cd904fa48710066dc68f64ce
Source dataset
uspto-grants-2010_06
Patent number
US07741321B2

Reaction notes

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