反应详情

A solution of diethyl-2-acetamido-2-{2-[4-(1-oxo-5-phenylpentyl)phenyl]ethyl}malonate (13.5 g), ethylene glycol (3.1 ml) and p-toluenesulfonic acid (0.53 g) in benzene (135 ml) was refluxed under heating for 20 hours, while dehydrating with Dean-Stark trap. The reaction mixture was treated with triethylamine (2.4 ml) and ethyl acetate (200 ml) was added thereto. The mixture was washed with water and saturated brine, dried over anhydrous sodium sulfate and the solvent was distilled away under reduced pressure to give a pale yellow oily substance (15.9 g). The obtained pale yellow oily substance was purified by silica gel column chromatography (eluent; hexane:ethyl acetate=1:1) to give diethyl 2acetamido-2-{2-[4-(1,1-ethylenedioxy-5-phenylpentyl)phenyl]ethyl}malonate (14.1 g) as a colorless transparent oily substance.

1. temperatureunder heating for 20 hours
2. additionwas added
3. washThe mixture was washed with water and saturated brine
4. dry with materialdried over anhydrous sodium sulfate
5. distillationthe solvent was distilled away under reduced pressure
6. customto give a pale yellow oily substance (15.9 g)
7. customThe obtained pale yellow oily substance was purified by silica gel column chromatography (eluent; hexane:ethyl acetate=1:1)