HCID 178427889, compound → HCID 178427891, compound

HRID 1795883Notes

Reaction equation

HRID 1795883 reaction equation
O1CCCCC1[O:7][NH:8][C:9]([C:11]1[C:19]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([I:27])=[CH:23][C:22]=2[CH3:28])=[C:18]([F:29])[C:14]2[NH:15][CH:16]=[N:17][C:13]=2[CH:12]=1)=[O:10]>Cl.CO.C(O)C>[OH:7][NH:8][C:9]([C:11]1[C:19]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([I:27])=[CH:23][C:22]=2[CH3:28])=[C:18]([F:29])[C:14]2[NH:15][CH:16]=[N:17][C:13]=2[CH:12]=1)=[O:10]

Participants

5

Reactant 1

HCID 178427889HCID 178427889, compound

Product 1

HCID 178427891HCID 178427891, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

The compound 7-fluoro-6-(4-iodo-2-methyl-phenylamino)-1H-benzoimidazole-5-carboxylic acid O-(tetrahydro-2H-pyran-2-yl)-oxyamide is dissolved in an appropriate hydrogen chloride-saturated solvent like methanol or ethanol. Once homogeneous, the solution is concentrated in vacuo to give the desired product. The product may be triturated with an appropriate solvent like chloroform or dichloromethane if further purification is necessary.

Workup

  1. concentrationOnce homogeneous, the solution is concentrated in vacuo

Sources & evidence

ORD record
ord-c2b31fa6000d49c2b59f92ac16342feb
Source dataset
uspto-grants-2006_04
Patent number
US07030119B1

Reaction notes

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