Sodium hydride → HCID 10299411, compound

HRID 1795927Notes

Reaction equation

HRID 1795927 reaction equation
Cl[CH2:2][C:3]1[O:4][C:5]2[C:11]([O:12][CH3:13])=[C:10]([O:14][CH3:15])[CH:9]=[C:8]([CH2:16][C:17]3[C:18]([NH2:24])=[N:19][C:20]([NH2:23])=[N:21][CH:22]=3)[C:6]=2[CH:7]=1.[H-].[Na+].[NH:27]([C:31]1[CH:36]=[CH:35][C:34]([SH:37])=[CH:33][CH:32]=1)[C:28]([CH3:30])=[O:29]>C(O)=O>[NH2:23][C:20]1[N:19]=[C:18]([NH2:24])[C:17]([CH2:16][C:8]2[C:6]3[CH:7]=[C:3]([CH2:2][S:37][C:34]4[CH:33]=[CH:32][C:31]([NH:27][C:28](=[O:29])[CH3:30])=[CH:36][CH:35]=4)[O:4][C:5]=3[C:11]([O:12][CH3:13])=[C:10]([O:14][CH3:15])[CH:9]=2)=[CH:22][N:21]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 707774'-MercaptoacetanilideHCID 22180823HCID 22180823, compound

Product 1

HCID 10299411HCID 10299411, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

formic acid salt (20 mg) was obtained by reacting 5-(2-chloromethyl-6,7-dimethoxy-benzofuran-4-ylmethyl)-pyrimidine-2,4-diamine (52 mg, 0.151 mmol), NaH (12 mg, 0.303 mmol), and 4-acetaminothiophenol (56 mg, 0.303 mmol).

Sources & evidence

ORD record
ord-0978f7b0fb374922a2cfc29c43ad135b
Source dataset
uspto-grants-2006_04
Patent number
US07030130B2

Reaction notes

Loading…