2,4-Dichloro-6-methylbenzenesulfonyl chloride → HCID 10297515, compound

HRID 1795929Notes

Reaction equation

HRID 1795929 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH2:10][CH:9]([NH:11][C:12](=[O:15])[CH2:13][CH3:14])[CH2:8][CH2:7][C:5]=2[N:6]=1.[Cl:16][C:17]1[CH:22]=[C:21]([Cl:23])[CH:20]=[C:19]([CH3:24])[C:18]=1[S:25](Cl)(=[O:27])=[O:26]>>[Cl:16][C:17]1[CH:22]=[C:21]([Cl:23])[CH:20]=[C:19]([CH3:24])[C:18]=1[S:25]([NH:1][C:2]1[S:3][C:4]2[CH2:10][CH:9]([NH:11][C:12](=[O:15])[CH2:13][CH3:14])[CH2:8][CH2:7][C:5]=2[N:6]=1)(=[O:27])=[O:26]

Participants

3

Reactant 2

HCID 28013872,4-Dichloro-6-methylbenzenesulfonyl chlorideHCID 22180927N-(2-Amino-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl)propanamide

Product 1

HCID 10297515HCID 10297515, compound

Procedure

The title compound was prepared from N-(2-amino-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl)propanamide (47 mg, 0.21 mmol) and 2,4-dichloro-6-methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (20.3 mg) with purity >90%. MS (pos) m/z 448.1, 450.1.

Sources & evidence

ORD record
ord-cb83fa3d00d742b7911c5036706b73a1
Source dataset
uspto-grants-2006_04
Patent number
US07030135B2

Reaction notes

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